CD Formulation provides a microinjection method for the minimally invasive transdermal administration of exenatide to address the short half-life of exenatide, the defects of establishing tolerance through multiple small injections, and the inconvenience and pain caused to patients by frequent injections.
CD Formulation offers preparation, formulation design and analytical testing services for exenatide microneedles, you can find the right procedure for any of your microneedle development steps with us.
Formulation design experiments can help you reduce your workload. Our formulators will efficiently design your formulation, analyze and compare it, and select the most suitable formulations for you.
CD Formulation can provide you with full analytical testing of microneedles, including morphology testing, swelling analysis, drug release assays, etc.
The prepared microneedles are observed under microscope and photographed, and the surface morphology of the microneedles is observed more clearly by Scanning Electron Microscope (SEM).
The ease of microneedle unmolding can be observed by adjusting the ratio of polymer and exenatide, and designing different prescription ratios to see whether the prescription is conducive to microneedle forming.
The analysis was performed by putting the wrapped microneedle tablets into water and immersing the needle tips into the water to perform the swelling experiment. The microneedle tablets were removed at different times, the water was aspirated from the microneedle tablets, the weight of the microneedle tablets was weighed, and the data was recorded. Graphs were made to examine the degree of swelling and the rate of swelling of the microneedle tablets.
CD Formulation can perform in vitro release assays for exenatide microneedles by exposing the microneedles to phosphate buffer, constant temperature, and shaker. Samples are taken and assayed using HPLC.
In order to verify the uniformity of exenatide dispersion in different parts of the same mold, the drug loading uniformity of microneedles can be examined. The release of exenatide at various time points in different parts of the microneedle tablets of the same mold can be examined, as well as the cumulative release profile, and thus the uniformity of microneedle loading can be assessed.
If you are interested in our services, please feel free to contact us.