As a new drug dosage form, in situ gel is widely used in new drug delivery systems such as extended release, controlled release and pulsed release. In situ gel can be applied in various routes of drug delivery such as subcutaneous or intramuscular injection, skin, eye, nasal and oral cavity. Based on the existing technology, experimental equipment and other factors, CD Formulation can provide technical support and product solutions for drug sustained release to help customers to rapidly develop and accelerate the commercialization of drugs.
In situ gels are a class of drug reservoirs that are administered in a relatively low viscosity liquid state and then rapidly transform their physical form to form a semi-solid gel at the site of administration. In situ gels have good histocompatibility and long retention time at the drug delivery site, and can also serve to store drugs and protect them from environmental influences. Depending on the formation mechanism, in situ gels can be classified as temperature-sensitive, pH-sensitive and ion-sensitive. The mechanisms of in situ gelation can be broadly classified into two categories, namely: physical changes, such as precipitation of polymers in non-aqueous solvents after injection, and chemical changes, such as cross-linking of prepolymers after injection.
CD Formulation's in situ gel slow release technology service can prolong the residence time of drugs in the body and release them continuously, reducing systemic absorption through local action, which can increase bioavailability and improve therapeutic effects. As new technologies and biodegradable materials continue to evolve, more and more in situ gel products can be developed.
If you would like to learn more about our technology, please feel free to contact us and we will get back to you as soon as possible.
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