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Injection Implant Technology for Drug Physicochemical Improvement

Injection Implant Technology for Drug Physicochemical Improvement

CD Formulation has a long-acting implant technology platform that can support implant products from research and development to commercial scale production. A long-acting sustained-release implant is a long-acting sustained-release drug system that is surgically implanted or needle injected subcutaneously or into other targeted sites. Long-acting implants are characterized by local or systemic drug delivery, reduced dose and side effects, avoidance of first-pass effects and gastrointestinal degradation, improved bioavailability, high drug loading capacity, smaller size, longer duration of drug action, especially suitable for long-term treatment of chronic and geriatric diseases, and improved patient compliance, etc.

CD Formulation has a long-acting implant technology platform that can support the development to commercial scale production of implantable products, and has a mature hot-melt extrusion implant preparation technology that can achieve continuous production and a high degree of industrialization.

Technology Background on Injectable Implants

Polymers are usually mixed with solvents and then injected for drug delivery. The solvent diffuses rapidly from the injection site and the polymer is transformed into a precipitate to form a biodegradable implant. The mechanism of drug release differs from that of microspheres in that the release of the implant is controlled by diffusion. Similar to microspheres, the aqueous environment surrounding the implant gradually degrades the polymeric backbone over time, resulting in further release of the drug saturated in the implant and a slow-release drug release profile. Injectable implants are easy to use, simple to prepare, have small abrupt drug release, high drug loading capacity, and better stability and sustained release.

Types of Designed Implants

Implants are available in various forms, such as tubular, rod, pill, tablet or membrane, and can also be in the form of micropumps. The basic structure, materials and preparation processes of implants vary, as do the release mechanisms, routes of administration and delivery sites.

Characteristics of Implants

(1) The drug release period is several months to several years, which reduces the trouble of continuous drug use.

(2) Due to the blocking effect of polymeric skeleton, the drug in the system is often released at a constant rate, so it can maintain a stable blood concentration and reduce the toxic side effects of the drug.

(3) The implant can eliminate the peaks and valleys of drug concentration due to intermittent drug administration, and can release the drug at a constant rate at a specific site to maintain a stable therapeutic concentration, which can achieve therapeutic effects with a small dose.

(4) It is suitable for long-term treatment of chronic and geriatric diseases and improves patient compliance.

(5) Less subcutaneous nerve distribution, less reaction to foreign bodies, and lower irritation and pain after implantation.

Injection implants are a very simple long-acting injectable technology that delivers drug release by diffusion control. CD Formulation can provide you with professional technical support for implants to help you develop your long-acting extended release program. If you would like our help, please do not hesitate to contact us at any time and our scientists will provide you with an exclusive solution.

Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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