|Carboxymethylcellulose sodium salt
The device in which microneedles have drug delivery significance is the microneedle array, in which many microneedles are arranged in an array on a drug delivery vehicle. Currently, a variety of materials can be used to prepare microneedles, including hard materials such as bioglass, silicon, and stainless steel, as well as flexible materials with good biocompatibility such as polyethylene glycol and its derivatives, hyaluronic acid and its derivatives, gelatin and its derivatives, and chitosan. Microneedles of different materials have different properties and uses.
The length of microneedles varies from a few hundred microns to a few millimeters, which can pass right through the skin stratum corneum without touching the nerve of pain, forming a drug delivery channel on the skin surface, allowing the drug to reach the specified depth of the skin and enter the subcutaneous capillary network to be absorbed, serving to promote drug penetration without causing pain or skin damage. Therefore, microneedling helps to improve the efficiency of drug delivery and improve patient compliance.
Microneedling is currently most widely used in the cosmetic field and has been commercialized for many years. While microneedle products applied to transdermal drug delivery are still in clinical trials, most microneedles are mainly used for vaccination, treatment of diabetes, transdermal delivery of intracellular DNA/RNA, etc., hair regeneration, treatment of skin cancer, etc. In recent years, the application of microneedles has gradually expanded to include the extraction or in situ detection of analytes (e.g., glucose, blood, biomarkers, etc.) via microneedles for biotransduction.
The microneedle platform has been used to design diagnostics through the use of microneedles. Microneedle platforms are used to design diagnostics to output medically relevant signals by evaluating external secretions (e.g., urine, saliva, sweat, tears, etc.) or body fluids (tissue fluids and blood). Since only low concentrations of biomarkers are required for diagnosis and with high accuracy, microneedles are considered ideal biosensing platforms capable of extracting or accessing subcutaneous body fluids in a minimally invasive manner to detect various analytes.
CD Formulation can provide you with raw materials for microneedles and offer you services and technologies for microneedle preparation. If you have a need for microneedle projects, please do not hesitate to contact us in time and we will provide you with high quality products and services.