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Erythropoietin Microsphere Preparation

Erythropoietin Microsphere Preparation

CD Formulation is a high-tech enterprise specializing in the production and application of microspheres and microneedles in the field of pharmaceutical preparations. The size of microspheres and microneedles is uniform and controllable, and their various functional indexes can be customized. CD Formulation is our supply of high quality pellet products to customers; Personalized and customized service for microspheres and microneedles products; OEM service for microspheres and microneedles products; Microspheres and microneedles product modification services; Total technical solutions for microsphere applications.

Erythropoietin Microsphere Preparation Technology

Erythropoietin (EPO), an active glycoprotein synthesized from the proximal curved tubules of the kidney, stimulates the proliferation and differentiation of bone marrow erythrocytes and regulates erythrocyte development. EPO plays a very extensive and complex role in neurodevelopment, neuroprotection, repair, survival and regeneration of adult neurons, and its neuroprotective effect is considered to be a direct effect independent of its ability to promote erythropoiesis. In addition, EPO and its Erythropoietin receptor (EPO-R) are expressed in neurons and glial cells of sentinel, mammalian and human species.

Erythropoietin microspheres are: one of the naturally extracted erythropoietin, gene recombinant expression erythropoietin, polyethylene glycol modified erythropoietin, glycosylated modified erythropoietin or human serum fused erythropoietin and polysaccharide prepared into erythropoietin polysaccharide granules. Erythropoietin microspheres were prepared by oil-in-water (S/O/W) method or oil-in-water (S/O/O/W) method.

The advantages of erythropoietin microspheres include: 1) it has the advantages of long-term slow release, non-toxic side effects, good compliance, relief of patient pain, low price, easy to be accepted by patients; 2) The preparation process is simple and environmentally friendly.

How to Prepare Erythropoietin Microspheres

CD Formulation provides professional preparation services of erythropoietin microspheres, including erythropoietin polysaccharide granules prepared with glucan or sodium alginate in polyethylene glycol solution by freeze-drying or spray drying, then erythropoietin microspheres were prepared by oil-in-water method or oil-in-water method.

Available sustained release materials

Polylactic acid (PLA), polyglycolate (PLGA), polycaprolactone (PCL), polylactic acid-polyethylene glycol (PLa-PEG), or polylglycolate-polylactic acid-polyethylene glycol (PLga-PEG).

Erythropoietin microsphere test

Determination of encapsulation rate, drug loading and release rate of microspheres. The microspheres were dissolved, the protein content in the solution was detected by the instrument, and then the encapsulation rate, drug loading and release rate of the microspheres were calculated.

Surface morphology and permeability test of microspheres

The surface morphology of the microspheres was observed by scanning electron microscope. The permeability of the microsphere can be detected by laser confocal microscopy. The fluorescence distribution inside the microsphere can reflect the diffusion of water in the outer water phase into the interior of the microsphere, thus reflecting the permeability of the microsphere.

Particle size distribution of microspheres

The particle size and distribution of microspheres were measured by laser particle size distributor.

In addition to the above services, we can also provide microsphere mechanical properties testing, including microsphere rupture strength, microsphere rigidity, microsphere elasticity, microsphere needle resistance, microsphere compression strength, etc. In the process of research and development of microspheres, high precision mechanical analysis instruments can be used to analyze the mechanical properties of microspheres such as the rigidity and recovery of microspheres in use. If you are interested in our services or need to customize the relevant tests for your microsphere products, please do not hesitate to contact our staff.

Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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